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Brief temperature excursions of a few hours are unlikely to cause significant degradation

10.1523/JNEUROSCI.20-24-09187.2000 J

The severity and frequency of these adverse events is dose-dependent, but both can be reduced with slower stepwise dose titration

B., Sr., DAgostino, R

After hypoxia, mitochondrial suspensions were isolated from the brains of these rats using the same technique as described above for polarographic measurements [2]

Headaches, fatigue, nausea and mental fog are all the result of physiological imbalances caused by dehydration, electrolyte loss, oxidative stress and a buildup of toxic byproducts like acetaldehyde