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The efficacy and safety of novel classes of glucose-lowering drugs for cardiovascular outcomes: a network meta-analysis of randomized clinical trials
Sweet tastants bind to receptor type 1 member 2 (T1R2 or TAS1R2) and member 3 (T1R3 or TAS1R3), but beside this well recognized mechanism, T1R-independent mechanisms appear to be implicated in sweet taste recognition [2728]
taken on an empty stomach or 30 minutes before meals to maximize contact with gastric and intestinal mucosa Duration 8 to 12 weeks per cycle, or longer under physician supervision for chronic GI conditions
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