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Hypoxia causes the production of ROS, which inhibit the degradation of the hypoxia-inducible factor 1 (HIF-1) (78)

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Protein-bound complexes formed by cisplatin can be retained in the body for a long time with a significantly prolonged elimination half-life, which serves as the core material basis for its long-term cumulative toxicities including nephrotoxicity and ototoxicity

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