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Breast reduction surgery offers the most predictable, permanent, and medically effective breast size reduction

This timing requirement limits its practical usefulness

Variability in free-living conditions: Differences in beverage preparation, timing, and adherence may have introduced outcome variability

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However, as with any medical treatment, it is crucial for patients considering PT-141 to discuss its potential benefits and risks with their healthcare provider, especially given the specific FDA approval for women and its off-label use in men