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Amgen will now be required to run an additional confirmatory study to be completed no later than February 2028, the company stated in a press release announcing the Complete Response Letter

Your provider may recommend monitoring for side effects like severe nausea or hypoglycemia

On the positive side, GLP1-S has demonstrated cardiovascular benefits in large outcome trials, with evidence suggesting a reduction in the risk of major adverse cardiovascular events in participants with type 2 diabetes

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And people are taking notice, a Gallup poll study reports that GLP-1 medications for weight loss purposes have risen to 11% in 2026, up significantly from 3% in 2024

GLP-1 is a naturally occurring peptide that plays a major role in appetite regulation and blood sugar control