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The added glucagon receptor increases resting energy expenditure, promotes liver fat clearance (82% reduction vs ~55%), and contributes to greater overall weight loss (28.7% vs 22.5%)

"Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial." Eli Lilly and Company , 11 Dec

Adequate protein (80-100g daily) and biotin supplementation help minimize this risk

It is best understood as a triple-agonist reference for metabolic receptor pharmacology

Anti-inflammatory effects of tirzepatide: a systematic review and meta-analysis