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As a secretory cell of GLP-1, it was stimulated by berberine and showed the same phenomenon of increased GLP-1 secretion as STC-1 cell, as well as increased expression of GLP-1R, p-PKA, Pdx1 and other related molecules
To induce long-term potentiation (LTP), Ca 2+ activates CAMKII and PKC, causing phosphorylation and insertion of AMPARs, while long-term depression (LTD) occurs by Ca 2+ activating protein phosphatases, which dephosphorylate and cause internalization of AMPARs
In Phase 1 trials, this drug improved glycemic control and weight in non-PWS individuals with obesity and type 2 diabetes
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