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In rodent studies, GLP-1 receptor agonists caused thyroid C-cell tumors, including medullary thyroid carcinoma

or when used with other medications [see Warnings and Precautions (5.4) and Drug Interactions (7)]

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Thyroid function monitoring should be intensified during the initial phases of GLP-1 treatment and during periods of significant weight loss

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A 2004 study by the University of Alabama found that the red blood cells in male Alzheimers patients showed a significant lack of glutathione