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Plasma levels decline significantly with age from approximately 200 ng/ml at age 20 to roughly 80 ng/ml by age 60

doi: 10.1016/0014-2999(90)90204-J

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Similar observations were made in aortic tissue slices, where FOXO4-DRI treatment led to increased expression of p-P53, mainly localized in the cytoplasm (Figures 5F,G)

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