It is most often based on the clinical symptoms together with laboratory assessment (low serum vitamin B 12 level and elevated serum homocysteine or methylmalonic acid level) and the response to treatment to make definitive diagnosis
The data generated during this phase help define the dose range that may be explored in subsequent studies and contribute to understanding exposure-response relationships, pharmacokinetic behavior and safety considerations associated with the investigational compound
The mechanism is epigenetic and enzymatic, not receptor occupancy-based.
Dosage is tailored to each person
Specifically, GHK activates genes involved in DNA repair, antioxidant defense, and stem cell function, while suppressing genes associated with chronic inflammation and fibrosis
With proper medical guidance, they are safe, effective, and easy to get