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Autocorrection of the serum sodium can occur after correction of the underlying causes, such as the administration of saline to patients with volume depletion, the discontinuation of drugs that cause the syndrome of inappropriate antidiuresis (SIAD), and discontinuation of diuretics

This is the same mechanism the body uses naturally during fasting, exercise or stress, AOD-9604 simply amplifies the signal

One commenter also suggested that CMS only require the 10th and 90th percentile allowed amount values when the count of allowed amounts is greater than 10, explaining doing so would better statistically capture true 10th and 90th percentile values and would, in outlier situations, address privacy concerns

This differs from patient to patient, and it often depends on the severity of the symptoms and any underlying health issues

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