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In vitro and in vivo activity of sEV-semaglutide and sEV-tirzepatide To investigate the in vitro and in vivo activity of sEV-semaglutide or sEV-tirzepatide, we utilized an in vitro cell assay (293 cell line that expresses both the hGLP-1R and CRE firefly luciferase) and an in vivo mouse model (db/db diabetic mice) 36

While potentially quicker and more convenient than IV therapy, injections may not offer the same sustained release of NAD+

Annu Rev Pharmacol Toxicol (2019) 59:55575

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