glp-1/gip receptor agonists GLP-1 – Peripheral Brain Mechanistic Pathways and Comparative Efficacy

Gastrointestinal Issues This is the most frequent complaint

Documented adverse events in preclinical models include behavioral hyperactivity, serotonergic overstimulation, and autonomic instability when combining serotonergic peptides with SSRIs or MAOIs at doses previously considered safe independently

Relamorelin administered twice daily enhanced gastric emptying and improved the vomiting severity score compared to that in the placebo, but it did not significantly improve other GI manifestations such as belly ache and satiety (129)

Presenting symptoms included fatigue, weight loss, foot ulcers, and poor sleep

Bergman AJ, Cote J, Yi B, et al

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