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Clinical trials demonstrate that people using GLP-1 medications achieve significant improvements in HbA1c (average blood sugar over three months) and fasting insulin levels

CrossRef Hormonal GutBrain Signaling for the Treatment of Obesity Eun Roh, Kyung Mook Choi International Journal of Molecular Sciences.2023

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The question is not which is "best" in the abstract, but which combinations make the most sense for a given situation

Cuthbertson Abstract Rationale: Glucagon-like peptide-1 (GLP-1) receptor agonists (liraglutide, semaglutide) and dual glucose-dependent insulinotropic polypeptide (GLP-1/GIP) receptor agonists (tirzepatide) are approved for treatment of type 2 diabetes (T2D) and obesity