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As of 2025, retatrutide remains an investigational compound and has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA)

In humans, atherosclerosis of precerebral arteries causes stroke through plaque disruption and artery-to-artery thromboembolism, and, in contrast to the mouse models, statins exert additional stroke-protective effects in humans through their anti-atherosclerotic and plaque-stabilizing effects

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By week 12, cumulative weight loss of 56% of baseline body weight is common in clinical trials, though individual results vary

Nephroprotective activities of quercetin with potential relevance to oxidative stress induced by valproic acid