That mechanism is the entire point, and it works: roughly 18% of US adults have tried a GLP-1 and about 12% are currently taking one (KFF Health Tracking Poll), according to KFF survey data
Zhao and V
However, to date, extensive RCTs have shown no correlation between specific GLP-1 RAs and increased cancer risk
A study of patients with T2MD and congestive heart failure found that their levels of ANP were increased, whereas blood pressure was decreased, indicating that the GLP-1R-ANP axis is only active in patients with congestive heart failure (123)
But the doses required (typically 5001,500 mg of berberine per day) are far beyond what a small patch can plausibly deliver through the skin, even before you account for the absorption barrier
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