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Endocrine aspects of opioid use and withdrawal Several drugs (not only opioid) are able to modulate the activity of the hypothalamicpituitaryadrenal (HPA) axis or the sympathetic nervous system, leading to an impaired secretion or activity of respectively cortisol or catechol-amines

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Retinoids work by binding to retinoic acid receptors in the nucleus, directly altering gene transcription

Reconstitution principles remain constant but volumes scale accordingly