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Discontinuation rates due to adverse events for patients randomized to placebo or orforglipron were 4.8% (orforglipron from Wegovy), 7.6% (placebo from Wegovy), 7.2% (orforglipron from Zepbound) and 6.3% (placebo from Zepbound)

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In cellular models of KAT6A syndrome, this specific combination successfully rescued cell bioenergetics, increased cellular NAD+/NADH ratios, and physically repaired the cells' histone acetylation levels