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Flavonoids can exert their pro-oxidant effects through various mechanisms, including the transient reduction of Cu 2+ to Cu + , the formation of ROS, and the potential disruption of components of the antioxidant defense system in the nucleus, such as glutathione and glutathione-S-transferase [300]

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Melatonin (N-acetyl-5-methoxy-tryptamine), a pleiotropic and multitasking molecule, is secreted from the pineal gland during the night under normal light-dark conditions