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The resulting acylcarnitine diffuses through the intermembrane space to the CAT-2 transporter , where the acyl is transferred across the membrane and reactivated to acyl-CoA

Data availability X-ray crystallographic data are available from the PDB under accession numbers 6U32 (reference), 7ZBA, 7ZBB and 7ZBD

For metformin users, the MHRA recommends periodic monitoring, especially in those with symptoms suggestive of B12 deficiency

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For some people, the nausea can be mild, but for others, it can be severe enough to cause vomiting