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In mammalian cells, ER stress leads to an integrated stress response involving the related transmembrane kinases Ire1, Ire1 and PKRlike ER kinase (PERK), and the transmembrane activating transcription factor 6 (ATF6) (Zhang & Kaufman, 2004)

A recent study suggested that LOX was associated with both formation and assembly of collagen network and subsequent LV adverse remodeling[25].We found that all four genes were differentially expressed in the GSE133054 dataset

The loss of functionality and adaptability of important biomolecules due to oxidative stress are two interdependent biological processes, which are among the important factors that mediate aging

Human off-target activity and interaction risks have not been adequately characterised

Mutations of key genes and non-coding regions in microbial genomes has facilitated overproducing strain development (Park et al., 2011

However, the more detailed mechanisms still need to be summarized through more studies