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In our study, FOXO4-DRI selectively induced apoptosis in senescent keloid fibroblasts by promoting the relocation of p53-pS15 from the nucleus to the cytoplasm, exhibiting similar clearance efficiency to that in normal skin fibroblasts

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This article summarizes what the preclinical work reports, what a regulator would note about the absent human dataset, and the self-reported community adverse-event picture

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