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however, many clinical trials fail, and patients experience an unsatisfactory treatment response, likely owing to IC/BPS phenotype heterogeneity and the use of non-targeted interventions

Adequate hydration and avoiding injection on an overly empty stomach may reduce headache occurrence

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Hale has published peer-reviewed work on amino acid metabolism and consults with compounding pharmacies on evidence-based formulation development

As an example, GSH depletion has been shown to promote pro-inflammatory microglial phenotypes and amplify astrocyte-microglia crosstalk (Vilhardt et al., 2017)

Initiating GLP-1 therapy in combination with FreeStyle libre provides greater benefit compared to GLP-1 therapy alone