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At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S -transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta

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By binding to these target receptors primarily within the hindbrain (such as the area postrema), it allows researchers to study central appetite-suppressing pathways, the deceleration of gastric motility, and homeostatic energy balance