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This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD (Gu et al., 2013), which may impair the conversion of pyruvate to acetyl-CoA, leading to mitochondrial dysfunction and accumulation of lactate and alanine

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While GLP-1s are still only FDA-approved for weight-loss purposes for people with a BMI of 30 or more and those who have a BMI of 27 or more with a related health condition, like high cholesterol, plenty of people with lower BMIs have begun using them

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If severe B12 deficiency with neurological involvement is suspected, treatment should be initiated promptly without waiting for test results, and specialist advice may be needed

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