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The liver samples of patients without BWS were collected under the Childrens Hospital of Philadelphia protocol # IRB 21-018450_AM13

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doi: 10.3389/fphys.2026.1826699 Received 09 March 2026 Revised 02 April 2026 Accepted 09 April 2026 Published 28 April 2026 Volume 17 - 2026 Edited by Satoko Shinjo, University of Padua, Italy Reviewed by Alejandra Tomas, Imperial College London, United Kingdom Emily Walker, Wayne State University, United States Updates Copyright 2026 Cruz, Puebla-Huerta, Troncoso, Silva-Pavez, Hidalgo-Fadic and Ahumada-Castro

Differently expressed GR and GPX induced by blue light which regulated GSSG-GSH cycle in glutathione metabolism Glutathione reductase (GR) is a key NADPH-dependent flavo-protein oxidoreductase which can catalyze the glutathione disulfide (GSSG) to reduced glutathione (GSH) and protect plant cells from oxidative damage induced by reactive oxygen species (ROS) burst [18]