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Activation of pro-opiomelanocortin (POMC) neurons stimulate secretion of -melanocyte stimulating hormone (-MSH), the neurotransmitter that serves as a ligand for MC4R

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Broader NHS availability would likely lag behind any initial regulatory approval

Examples include: Rybelsus (oral semaglutide) an oral GLP-1 medication primarily approved for type 2 diabetes, though it may be considered in selected cases