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Furthermore, it has been demonstrated that TGF- activates a number of other non-canonical (non-Smad) signal pathways in different cell types, such as mitogen-activated protein kinases (extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38), phosphatidylinositol-3-kinase, and GTPases that resemble Rho ( Figure 6 ) (108)

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Semaglutide (CagriSema) The most extensively studied cagrilintide combination pairs it with semaglutide: The CagriSema combination demonstrates that adding amylin pathway activation to GLP-1 agonism produces substantially greater weight loss than GLP-1 therapy alone[9]