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Therefore, the development of an oral delivery strategy for peptide GLP-1R agonists is expected to reduce these adverse effects and improve patient compliance and quality of life (Borner et al., 2020
The effects of glutathione also neutralizes free radicals and reactive oxygen species, preventing oxidative damage caused by toxins
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Through a series of enzyme-driven reactions, Phase 1 alters the structure of toxins via: Oxidation introducing oxygen to increase chemical reactivity Reduction removing oxygen to alter molecular configuration Hydrolysis breaking chemical bonds using water Hydration adding water molecules to facilitate further processing Dehalogenation removing halogen atoms such as chlorine or bromine The purpose of Phase 1 is not elimination, but activation
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