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--- ## Storage Rules After Reconstitution | Condition | Temperature | Maximum Duration | |-----------|-------------|-----------------| | Refrigerator (ideal) | 3646F (28C) | 28 days from reconstitution | | Room temperature (brief excursion) | Under 77F (25C) | 2 hours maximum | | Frozen | Below 32F | Never discard immediately | **Storage do's:** - Store in the original vial, upright - Keep in the refrigerator door shelf or middle shelf avoid the back where freezing can occur - Protect from light (store in original box or wrap in foil) - Remove from fridge just before drawing your dose
Weight reduction is an evidence-based therapy for GERD, so the weight loss achieved with GLP-1 medications may actually improve reflux symptoms in many patients, potentially offsetting any direct effects on gastric emptying
If patients respond well and experience minimal side effects, the dose can be increased to 50 mg twice daily or adjusted further as clinically appropriate
This feedback loop will affect future pricing: for example, an approval contingent on future cost-effectiveness (like NICEs cancer drugs fund) can either confirm or revoke initial pricing
10.1016/j.biopha.2022.113360 Biomed
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