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However, in genotype 1a replicons, the C316Y substitution has low replication capacity that must be compensated for by additional compensatory substitutions, including L392F or M414T, resulting in an increase in replication levels of at least 10-fold [19]

Patients should check current availability with their healthcare provider and pharmacy, as supply constraints may affect access to certain products

To view a copy of this licence, visit About this article Cite this article Lui, D.T.W., Tsoi, K.H., Fong, C.H.Y

An otherwise healthy individual with T2D with an HbA1c level of 6.0% had a health state utility of 0.85 in the model 39

These combinations can address multiple aspects of disease pathophysiology and provide better glycemic control than individual therapies

Symptom burden: multiple symptoms and their impact as patient-reported outcomes