Insurance Barriers: May not cover for weight loss (only approved for diabetes) Requires type 2 diabetes diagnosis for coverage Extensive prior authorization requirements May require trying other medications first High copays even with coverage Supply Shortages: Both Mounjaro and Zepbound have experienced periodic shortages since launch, making consistent access difficult
Values closest to the 180-, 360-, and 540-day time points were used if multiple follow-up values were available
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For context on filler volume needs: McKinsey 2025 reported that 61% of GLP-1 aesthetic patients have lost 11 to 30% of their body weight, a magnitude of loss that typically requires multiple syringes for full initial correction (clinical practice patterns reported by aesthetic providers suggest 4 to 8 syringes initially, then 2 to 4 syringes annually for maintenance, though syringe counts vary substantially by individual anatomy and zones treated)