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UC is an intractable disease with repeated remission and relapse

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For example, the constrained energy model posits that humans and other animals share a set of evolved mechanisms to maintain TEE within a narrow range, dynamically compensating to changes in physical activity to keep daily expenditure in check [5] On the other side, the additive energy model suggests that increased physical activity has its own energy or Calorie cost, and this energy is added to the total energy expenditure the individual had before undertaking an exercise program