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Tirzepatide ( Zepbound ): A combination GLP-1 agonist and GIP agonist, which acts similarly to liraglutide and semaglutide

The pill was included in a November 2025 deal to be offered through the TrumpRx platform

Future of GLP-1 Medications: In Development: Oral formulations (Rybelsus exists but less effective) Monthly injection versions Triple agonist medications (GIP/GLP-1/glucagon) Combinations with other weight loss mechanisms The GLP-1 class will likely dominate weight loss treatment for the next decade while continuing to improve

These constitute the neural pathway that connects the visceral sensory brainstem and the hypothalamic nucleus to participate in energy homeostasis

Kipnis adds

Yet with preclinical trials ongoing, the list of insurance-approved uses could soon expand to include sleep apnea (which can be weight-related), Parkinsons, dementia, and more