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The cause affects which treatment works best Medical history: Existing conditions, medications, and allergies that may interact Treatment goals: Whether the patient wants overall brightening, spot reduction, or both This step is what separates a safe, effective outcome from a disappointing or harmful one

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in fact, it is estimated male factors play a role in roughly 50% of couples with infertility

The studies were divided into three categories: high risk of bias, low risk of bias, and uncertain risk of bias

doi:10.1212/CPJ.0000000000000043 In addition, there are several limitations in the research that has been conducted, such as: Many studies do not include the use of fluoroscopy or x-ray to verify the proper placement of the medication despite the fact that fluoroscopic guidance is routinely used today

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