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Trx1 promotes reverse cholesterol transport (Figure 3) via nuclear translocation of liver X receptor and subsequent increase of ATP-binding cassette transporter A1 expression, thereby inhibiting hepatic steatosis [98] , a disease condition linked to ferroptosis [99]

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MiR-25 is overexpressed in both keratinocytes and melanocytes in response to oxidative stress, which decreases the activity of antioxidant enzymes and impairs melanosome transport, leading to redox imbalance [51]

Human results are not established, and large human trials have not been completed, which is a critical limit to keep in mind