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But why has no synthetic pathway evolved that leads directly to the synthesis of L-malate

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While many trials have found 500mg to be potentially suitable for a wide range of health concerns, other research has found that 1,000mg may be the ideal dose for some needs (e.g., 500mg improved measures of leg strength, while 1,000mg improved aerobic endurance).5 But, out of our picks, only Mitopure has been subjected to multiple studies

In some situations, pharmacies may prepare compounded versions of certain medications

You're working from plausibility and anecdotal clinical experience, not controlled human trials