Diarrhea might happen shortly after starting the medication or when the dose is increased
Sheu, M
Treatment continuation requires demonstration of adequate response: For liraglutide: at least 5% weight loss after 12 weeks at the maintenance dose of 3.0 mg For semaglutide: assessment after approximately 3 months at the maintenance dose of 2.4 mg, with discontinuation if less than 5% weight loss achieved Private prescribing is available but costs vary by provider and medication
Scholtens RM, van Munster BC, van Kempen MF, de Rooij SE
doi: 10.1038/mi.2014.107 220 Abad-FernndezMVallejoAHernndez-NovoaBDazLGutirrezCMadridNet al
These obstacles can be overcome by Dihexa, a synthetic, small molecule HGF mimetic that is orally bioavailable, metabolically stable, blood-brain barrier permeable, and inexpensive to synthesize (McCoy et al., 2013)