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That small molecular size is the defining advantage: these peptide fragments can cross the blood-brain barrier and interact directly with neurons, something that most endogenous neurotrophic factors cannot do on their own

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The National Resource Center for Nutrition and Aging confirms there is no set upper-level limit for vitamin B12 dosage

PMID: 39 HassanniaB.VandenabeeleP.Vanden BergheT

International Journal of Cosmetic Science