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Imbalance in mitochondrial fission and fusion is a key trigger for Parkinsons disease, and defects in mitochondrial dynamics limit mitochondrial movement, leading to a reduction in ATP, excessive oxidative stress, and mtDNA deficiency, which ultimately leads to cell death (Geng et al., 2019)

doi: 10.1128/AEM.03565-12 12 SalvanoMALisaTADomenechCE

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Cederbaum, A

Cells with above-average distance as well as above-average distance normalized by the cells Ferets diameter were regarded as cells with a true peripheral lysosome phenotype