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Funding This work was supported by a R01MH128311 and a R56MH125895 to CN

A predicted outcome of TGR inhibition in worms is the accumulation of oxidized GSH (GSSG) because of attenuated reduction to GSH by TGR, leading to decreases in the GSH/GSSG ratio

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Ali Rezaie, Medical Director of Gastroenterology Motility at Cedars-Sinai Medical Center, emphasized that while the relative risk increases by 33%, the absolute risk remains low at 0.2%

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