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The inability to sustain weight loss may be due to PYY 3-36 -induced Y2-R down-regulation and tolerance (i.e., tachyphylaxis) and/or activation of compensatory mechanisms in response to reduced food intake

A high-fiber diet can cause gastrointestinal discomforts, such as gas, bloating, and constipation in patients with Crohns disease, irritable bowel syndrome, or ulcerative colitis

We explore glucagon, GIP, triple agonists, and emerging innovations shaping metabolic medicine

L-cells express numerous receptors that detect specific nutrients: glucose transporters (such as SGLT1) sense carbohydrates, G-protein coupled receptors detect fatty acids, and amino acid transporters recognise proteins

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SMFH and TCM phytochemicals are promising therapeutic drugs for treating AKI