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Side effects, safety, and tolerability Both medications (tirzepatide and orforglipron) are GLP-1-based and share the same side effects profile as other GLP-1 receptor agonists used for diabetes and weight management

Previous studies suggested potential GLP-1 receptor expression in hepatocytes

Many will note this in your chart and adjust their assessment accordingly

But aside from those that are approved as therapeutic medications, the manufacturing of certain peptides is largely unregulated

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Statistical analysis Cross-sectional analyses estimated the proportion of women achieving each outcome using odds ratios with risk differences and 95% confidence intervals, derived from propensity-matched cohorts