Carter BZ, Mak PY, Tao W, Warmoes M, Lorenzi P, Mak D, Ruvolo V, Wang X, Tan L, Cidado J, Drew L, Andreeff M
Risk of bias for each study was assessed using the Cochrane Risk of Bias 2.0 (RoB 2) tool, covering five domains: Randomization process
For example, single-dose administration is often used in experiments investigating acute responses like changes in gastric emptying
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Increased GST and/or GT tumor expression, generally considered as a bad prognosis marker (associated with drug resistance and disease progression), and could potentially be used as a predictive marker, allowing doctors, after biopsy, to identify which patients will respond best to GST or GT-activated prodrugs
Yes and combination is recommended for faster visible results