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Marine microplastic debris: an emerging issue for food security, food safety and human health

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The pathways that regulate self-renewal of CSCs include wint (Wnt), Notch, Hedgehog, and tumor-suppressor genes such as PTEN and TP53 (tumor protein 53) [294]

Given that cancer development is a multistep process, it is essential to determine whether PET MNPs can interfere with key signalling pathways involved in cell survival and proliferation, thereby contributing to tumour initiation or progression