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Contrave's long-term data, while limited, suggests some weight regain after the initial loss phase, though participants generally maintained weight below baseline levels

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[DOI] [PubMed] [Google Scholar] 36.Yu F.H., Mantegazza M., Westenbroek R.E., Robbins C.A., Kalume F., Burton K.A., Spain W.J., McKnight G.S., Scheuer T., Catterall W.A

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Wegovy is FDA-approved for weight loss for those with a body mass index (BMI) 30 or 27 with one or more weight-related comorbidities, such as heart disease or untreated high blood pressure