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Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial

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revealed that, although changes within the phylum Firmicutes are heterogeneous, butyrate-producing generasuch as Faecalibacterium, Roseburia, and Coprococcusare significantly reduced, whereas Proteobacteria expanded and Bacteroidetes decreased (Qin et al., 2012), The number of Bifidobacterium (Li et al., 2023) decreased, while randomized studies suggested an increase in Bacteroides (Zhang et al., 2025)