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In another phase II trial with 52 people with clinical evidence of NASH, liraglutide 1.8 mg treatment led to histological improvement of NASH [79]

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Research into GLP-1 and thermoregulation remains sparse, which is partly why this risk isnt yet plastered across patient information leaflets

Advancements in targeted delivery methods and selective prodrugs are crucial to reduce off-target effects

Both the 2016 consensus statement of the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) on management of type 2 diabetes and the 2016 American Diabetes Association (ADA) standards recommend adding on GLP-1 RAs to patients not meeting treatment goals with basal insulin