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PAR2-G37I and PAR2-R38E mice on a normal chow diet (NCD) showed no differences in body weight, fasting glucose, and insulin levels compared with WT mice (Supplemental Figure 5, AC)

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Wang et al, 2022

Weeks 21+ (10-12mg): maximum efficacy The 12mg dose is the highest tested in clinical trials, and it delivers the most dramatic results

remove caps with a straight pulling motion along the needle's axis, never a twisting or lateral force