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Semaglutide exerts its therapeutic effects through several mechanisms: Enhancing glucose-dependent insulin secretion from pancreatic beta cells Suppressing inappropriate glucagon release Slowing gastric emptying, particularly during early treatment Reducing appetite through central nervous system pathways The slowing of gastric emptying, whilst beneficial for glycaemic control and weight management, creates conditions that may contribute to belching and gas formation

Sources & References Eli Lilly press release: TRIUMPH-1 Phase 3 topline results

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doi:10.1016/j.cmet.2019.08.021 163

Table 1 Formation of major oxidants

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